Tandem mass spectrometry is a technique very similar to “single” GC-MS, but allows even lower limits of quantification.
After leaving the chromatographic column, the analytes go to a tandem mass spectrometer (MS / MS), commonly known as a triple quadrupole, which consists of two scanning mass analyzers (quadrupoles), separated by a collision chamber. The fragments selected in the first quadrupole are reacted with an inert gas in the collision chamber, resulting in further fragmentation.
During the development of the analytical method, the analyst selects the ions of the highest intensity – this is how the so-called MRMs.
Application:
In the laboratory, this system is most often used to determine the PAH content in various matrices. We also often use it for applications where the highest sensitivity is required.
